- Seattle, Washington
- Sedalia, Colorado
- Sedona, Arizona
- Senath, Missouri
- Seneca, South Carolina
- Sevierville, Tennessee
- Sewanee, Tennessee
- Shakopee, Minnesota
- Sharpsburg, Georgia
- Shawnee, Oklahoma
- Sheboygan, Wisconsin
- Shelby, Michigan
- Shelbyville, Tennessee
- Shell Knob, Missouri
- Shelter Island, New York
- Sheridan, Colorado
- Shreveport, Louisiana
- Sidman, Pennsylvania
- Siloam Springs, Arkansas
- Silver City, New Mexico
- Skokie, Illinois
- Slaughters, Kentucky
- Slippery Rock, Pennsylvania
- Smithfield, North Carolina
- Smithfield, Virginia
- Smithville, Tennessee
- Smyrna, Georgia
- Snowmass, Colorado
- Snyder, Texas
- Solon, Ohio
- Somerset County, New Jersey
- Somerset, Pennsylvania
- Somerville, Massachusetts
- Somerville, Tennessee
- South Charleston, West Virginia
- South Chesterfield, Virginia
- South Gate, California
- South Haven, Michigan
- South Holland, Illinois
- South Kingstown, Rhode Island
